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豆豆

发布日期:2023-03-06    来源:必威BETWAY官网     点击:
职称



豆豆

副教授

研究方向:抗病毒药物、抗肿瘤药物

联系方式:hlyxdou@163.com

主讲课程

《药物毒理学》《生药学》

教育背景

华东理工大学  药学专业  博士(2016-2022

河北科技大学  制药工程专业  学士(2012-2016

代表性学术成果

  1. Dou Dou,§ Yanyan Diao,§ Wenjie Sha,§ Rongrong Su, Linjiang Tong, Wenjie Li, Limin Leng, Lijuan Xie, Zhixiao Yu, Haoming Song, Zihao Shen, Lili Zhu, Zhenjiang Zhao, Hua Xie, Zhuo Chen,* Honglin Li,* and Yufang Xu.* Discovery of pteridine-7(8H)-one derivatives as potent and selective inhibitors of Bruton’s Tyrosine Kinase (BTK). J. Med. Chem. 2022, 65, 2694-2709.

  2. Dou Dou,§ Jie Wang,§ Yunjin Qiao,§ Gulinuer Wumaier,§ Wenjie Sha,§ Wenjie Li, Wenyi Mei, Tingyuan Yang, Chen Zhang, Huan He, Caolin Wang, Linna Chu, Baihui Sun, Rongrong Su, Xiangyu Ma, Mengdie Gong, Lijuan Xie, Wenzhe Jiang, Yanyan Diao, Lili Zhu, Zhenjiang Zhao, Zhuo Chen,* Yufang Xu,* Shengqing Li,* and Honglin Li.* Discovery and optimization of 4-anilinoquinazoline derivatives spanning ATP binding site and allosteric site as effective EGFR-C797S inhibitors. Eur. J. Med. Chem. 2022, 244, 114856.

  3. Dou Dou,§ Wenjie Sha,§ Yanyan Diao,§ Rongrong Su, Yunjin Qiao, Zhixiao Yu, Zhenjiang Zhao, Honglin Li,* Zhuo Chen,* Yufang Xu* Discovery of pyrido[3,4-b]indol-1-one derivatives as novel non-covalent Bruton’s tyrosine kinase (BTK) inhibitors. Bioorg. Chem. 2022, 119, 105541.

  4. Mengzhen Lai,§ Peiran Song,§ Dou Dou,§ Yanyan Diao, Lin-jiang Tong, Tao Zhang, Hua Xie,* Honglin Li,* Jian Ding.* Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2Hpyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton’s tyrosine kinase inhibitors. Acta Pharmacol. Sin. 2020, 41, 415-422.