姓    名：张康

职    称：教授

博士生导师\硕士生导师

研究领域：生物信息学，植物微生物互作

招生方向：生物化学与分子生物学，生物信息学、生物与医药

联系方式：zk7588@163.com

2012.9—2017.6，中国农业大学，生物信息学，理学博士（直博）

2008.9—2012.6，河北大学，生物科学，理学学士

工作经历

2017.9至今，必威BETWAY官网分子生物学与生物信息学系

荣誉称号及社会兼职

1.河北省植物生理与分子生物学会常务理事（2024-）

教学工作（本科生、研究生）

本科生课程：

1. 专业核心课《系统生物学》

2. 专业选修课《生物信息技术前沿》

研究生课程：

1.《功能基因研究进展》

主要研究方向及领域

目前的研究方向主要包括：

1）表观遗传学与植物抗病；

2）植物病原真菌致病机制；

3）生物信息数据平台。

主持课题项目

1. 国家自然科学基金面上项目，ZmREL2乙酰化参与JA信号通路调控玉米抗茎腐病的机制研究，50万元，2024.1-2027.12，主持；

2. 国家自然科学基金青年项目，玉米组蛋白去乙酰化酶HDA101参与抵抗禾谷镰孢侵染的机制研究， 25万元，2020.1-2022.12，主持；

3. 河北省教育厅青年拔尖人才项目，ZmBT4调控玉米抵抗禾谷镰孢侵染的分子机制，9万元，2022.4-2024.12，主持；

4. 河北省自然科学基金，玉米组蛋白去乙酰化酶HDA101参与抵抗禾谷镰孢侵染的调控机制， 6万元，2019.1-2021.12，主持；

5. betway必威引进人才项目，拟南芥MYB73参与抗病的分子机制，20万元，2017.9-2022.12，主持；

6. 国家自然科学基金面上项目，灰葡萄孢犬尿氨酸途径关键酶基因BcKMO影响病菌致病力的机制，2020.01-2023.12，59万元，排名第2；

7. 河北省重点研发计划项目，植物多功能复合微生态制剂的研发与应用， 2019.07-2022.06，45万元，排名第3。

   代表性学术成果

   研究论文（*通讯作者）：

   1. Fan Zhou, Yonggui Wang, Pengfei Liu, Wenxiao Ma, Ruobing He, Hongzhe Cao, Jihong Xing, Kang Zhang*, Jingao Dong*. Function of ZmBT2a gene in resistance to pathogen infection in maize. Phytopathology Research. 2024, 6: 43.

   2. Fuyuan Zhang, Hongzhe Cao, Helong Si, Jinping Zang, Jingao Dong, Jihong Xing, Kang Zhang*. FGCD: a database of fungal gene clusters related to secondary metabolism. Database (Oxford), 2024, baae011.

   3. Hongzhe Cao*, Kang Zhang*, Wei Li*, Xi Pang, Pengfei Liu, Helong Si, Jinping Zang, Jihong Xing, Jingao Dong. ZmMYC7 directly regulates ZmERF147 to increase maize resistance to Fusarium graminearum. Crop Journal, 2023, 11(1): 79-88.

   4. Ma Yuxin, Zhou Zhijun, Cao Hongzhe, Zhou Fan, Si Helong, Zang Jinping, Xing Jihong*, Zhang Kang*, Dong Jingao*. Identification and expression analysis of sugar transporter family genes reveal the role of ZmSTP2 and ZmSTP20 in maize disease resistance. Journal of Integrative Agriculture, 2023,22(11): 3458-3473.

   5. Kang Zhang, Lixia Jia, Helong Si, Jihong Xing, Jingao Dong, and ZhiyongLi. The first genome sequence resource of Tilletia setariae, the causal agent of Foxtail millet stinking smut disease. Phytopathology, 2022, 112:2574-2576.

   6. Kang Zhang, Hongzhe Cao, Yuxin Ma, Helong Si, Jinping Zang, Hua Bai, Lu Yu, Xi Pang, Fan Zhou, Jihong Xing and Jingao Dong. Global analysis of lysine 2-hydroxyisobutyrylation during Fusarium graminearum infection in maize. Frontiers in Plant Science, 2022, 13:1000039.

   7. Kang Zhang, Liming Wang, Helong Si, Hao Guo, Jianhu Liu, Jiao Jia, Qianfu Su, Yanbo Wang, Jinping Zang, Jihong Xing, and Jingao Dong. Maize stalk rot caused by Fusarium graminearum alters soil microbial composition and is directly inhibited by Bacillus siamensis isolated from rhizosphere soil. Frontiers in Microbiology, 2022, 13:986401.

   8. Si Helong*, Zhang Kang*, Li Bai*, Yuan Xuemei, Zang Jinping, Cao Hongzhe, Xing Jihong, Dong Jingao. BcSDR1 is involved in regulation of glucose transport and cAMP and MAPK signaling pathways in Botrytis cinerea. Journal of Integrative Agriculture, 2022, 21(9): 2628-2640.

   9. Fushun Wang*, Kang Zhang*, Ruolan Zhang, Hongquan Liu, Weijin Zhang, Zhanxiao Jia, and Chunyang Wang. PolyReco: A method to automatically label collinear regions and recognize polyploidy events based on the KS dotplot. Frontiers in Genetics, 2022, 13:842387.

   10. Fushun Wang, Ruolan Zhang, Xiaohua Sun, Junhao Wang, Hongquan Liu, Kang Zhang*, Chunyang Wang*. An intelligent recognition method of chromosome rearrangement patterns based on information entropy. Scientific Reports, 2022, 12:19707.

   11. Hua Bai, Helong Si, Jinping Zang, Xi Pang, Lu Yu, Hongzhe Cao, Jihong Xing*, Kang Zhang*, Jingao Dong*. Comparative proteomic analysis of the defense response to Gibberella stalk rot in maize and reveal that ZmWRKY83 is involved in plant disease resistance [J]. Frontiers in Plant Science, 2021, 12:694973.

   12. Zhiyan Cao*, Kang Zhang*, Xiaoyue Guo, B Gillian Turgeon, Jingao Dong. A genome resource of Setosphaeria turcica, causal agent of northern leaf blight of maize. Phytopathology, 2020, 110(12):2014-2016.

   13. Kang Zhang*, Lu Yu*, Xi Pang, Hongzhe Cao, Helong Si, Jinping Zang, Jihong Xing, Jingao Dong. In silico analysis of maize HDACs with an emphasis on their response to biotic and abiotic stresses. PeerJ, 2020, 8: e8539.

   14. Kang Zhang*, Xuemei Yuan*, Jinping Zang*, Min Wang, Fuxin Zhao, Peifen Li, Hongzhe Cao, Jianming Han, Jihong Xing, Jingao Dong. The kynurenine 3-monooxygenase encoding gene, BcKMO, is involved in the growth, development, and pathogenicity of Botrytis cinerea. Frontiers in Microbiology, 2018, 9:1039.

   15.Yue Liu*, Tian Tian*, Kang Zhang*, Qi You, Hengyu Yan, Nannan Zhao, Xin Yi, Wenying Xu, Zhen Su. PCSD: A plant chromatin state database. Nucleic Acids Research, 2018, 45, D1157-D1167.

   16. Kang Zhang, Wenying Xu, Chunchao Wang, Xin Yi, Wenli Zhang, Zhen Su Differential deposition of H2A.Z in combination with histone modifications within related genes in rice callus and seedling. Plant Journal, 2016, 89(2):264-277.

   17. Kang Zhang*, Qian Song*, Qiang Wei*, Chunchao Wang, Liwei Zhang, Wenying Xu, Zhen Su. Down-regulation of OsSPX1 caused semi-male sterility, resulting in reduction of grain yield in rice. Plant Biotechnology Journal, 2016, 14(8): 1661-1672.

    

   发明专利：

8. 张康, 邢继红, 杜月, 郭浩, 曹宏哲, 司贺龙, 董金皋. 一株贝莱斯芽孢杆菌及其在植物病害防治中的应用. ZL202111499658.8, 2021-12-09.

    

   创新创业竞赛获奖：

   1. 2021，河北省“挑战杯”全国老员工课外学术科技作品竞赛特等奖，第一指导教师；

   2. 2022，河北省“挑战杯”全国老员工课外学术科技作品竞赛一等奖，第一指导教师；

   3. 2023，河北省“挑战杯”全国老员工课外学术科技作品竞赛二等奖，第二指导教师；

   4. 2023，河北省“挑战杯”全国老员工课外学术科技作品竞赛三等奖，第一指导教师。